Feedback regulations from adipose tissue (fat)

The adipose tissue plays a central role in the long-term regulation of the food intake.

When we gain body fat, the fat cells increase the leptin release, affecting the satiety cells in the hypothalamus, and we decrease our food intake, decreasing the energy storage.

When we lose body fat, the leptin release is decreasing, the hunger cells in  the hypothalamus are stimulated, increasing the food intake, increasing the energy storage.

The leptin reduction during weight loss is one of the reason of being difficult to maintain a diet indefinitely.

In the next post i will write about the energy value of the nutrients.